Comparison of the intracellular pharmacokinetics of doxorubicin and 4′-epi-doxorubicin in patients with acute leukemia
✍ Scribed by Ulf Tidefelt; Britt Sundman-Engberg; Christer Paul
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 537 KB
- Volume
- 24
- Category
- Article
- ISSN
- 0344-5704
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To determine if there is a relationship between development of acute doxorubicin toxicity, pretreatment liver function studies, and response, 64 acute nonlymphocytic leukemia patients undergoing induction chemotherapy with doxorubicin and cytosine arabinoside were evaluated. No statistically signifi
## Abstract ## Background In adults, it has been shown that the pharmacokinetics of doxorubicin are highly variable, despite standardization of the dose based on body surface area (BSA). The purpose of this study was to determine the plasma concentrations of doxorubicin and its active metabolite d