## Abstract Liver transplantation represents a unique model for studying hepatitis C virus (HCV) evolution. In the current study, we estimated the dynamics of HCV quasispecies evolution over a period of 2.5 years both in sera and in tissues, including three different anatomic sites of the liver in
Comparison of the hypervariable region of hepatitis C virus genomes in plasma and liver
β Scribed by Naoya Sakamoto; Nobuyuki Enomoto; Masayuki Kurosaki; Yasuhiro Asahina; Shinya Maekawa; Kazuhiko Koizumi; Ikuo Sakuma; Takeshi Murakami; Fumiaki Marumo; Chifumi Sato
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 510 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0146-6615
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## Abstract Hepatitis C virus (HCV) infection is characterized by persistence of liver inflammation that often leads to endβstage liver disease, although the mechanisms are not fully understood. A hyperβvariable region (HVR) has been reported in the E2/NS1 region of the HCV genome, in which strikin
To investigate the potential clinical utility of antibody response to HVR1 of HCV, the genomic and amino acid diversity of HVR1 was compared between two groups of four chronic HCV carriers with or without liver cirrhosis. Peptides corresponding to the deduced COOH-and NH2terminal amino acid sequence