Comparison of the high relaxivity Gd chelates P1152 and Gd-BOPTA for contrast-enhanced MR angiography in rabbits at 1.5 Tesla and 3.0 Tesla

✍ Scribed by Kersten Peldschus; Mareike Hamdorf; Philippe Robert; Marc Port; Gerhard Adam; Christoph U. Herborn

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 398 KB
• Volume: 32
• Category: Article
• ISSN: 1053-1807
• DOI: 10.1002/jmri.22261

✦ Synopsis

Abstract

Purpose:

To compare signal‐enhancing properties of the high relaxivity Gd chelates P1152 and Gd‐BOPTA for contrast‐enhanced MR angiography (CE‐MRA) in rabbits at 1.5 Tesla (T) and 3.0T.

Materials and Methods:

Three‐dimensional CE‐MRA of the abdominal vasculature was performed in six rabbits using both contrast agents at a dose of 0.1 mmol/kg. Data acquisition was carried out during first pass and up to 10 min after contrast material administration. CNR was determined in aorta, vena cava, and renal cortex. Image quality (5‐point scale, 5 = best) of first pass MR angiograms was rated by two radiologists.

Results:

During first pass CNR of the aorta was 55.1 ± 5.8 (P1152) and 40.3 ± 3.9 (Gd‐BOPTA) at 1.5T (P < 0.05), and 114.9 ± 9.9 (P1152) and 73.5 ± 8.1 (Gd‐BOPTA) at 3.0T (P < 0.05). Both contrast agents showed a comparable decline of CNR within 10 min. Image quality was rated 4.8 ± 0.40 (P1152) and 4.5 ± 0.50 (Gd‐BOPTA) at 1.5T (P = 0.17), and 4.8 ± 0.37 (P1152) and 4.7 ± 0.47 (Gd‐BOPTA) at 3.0T (P = 0.61).

Conclusion:

The high relaxivity Gd‐chelate P1152 offers potential to improve image contrast for CE‐MRA compared with a clinically approved high relaxivity contrast agent. J. Magn. Reson. Imaging 2010;32:459–465. © 2010 Wiley‐Liss, Inc.