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Comparison of the efficacy of 7-hydroxystaurosporine (UCN-01) and other staurosporine analogs to abrogate cisplatin-induced cell cycle arrest in human breast cancer cell lines

✍ Scribed by Sang I Lee; Mary Kay Brown; Alan Eastman


Book ID
113994589
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
675 KB
Volume
58
Category
Article
ISSN
0006-2952

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Derivatives of camptothecins, topoisomerase I inhibitors and 7-hydroxystaurosporine (UCN-01), a protein kinase C (PKC) inhibitor and cell cycle checkpoint abrogator, are promising anticancer drugs. We characterized the apoptotic response to camptothecin and UCN-01 for the 8 human breast carcinoma ce