Comparison of the effects of tamoxifen and toremifene on rat hepatocarcinogenesis
✍ Scribed by Annukka Kärki; Eero Mäntylä; Yrjö Hirsimäki; Stefan Karlsson; Sakari Toikkanen; Pirkko Hirsimäki
- Book ID
- 105871089
- Publisher
- Springer-Verlag
- Year
- 2000
- Tongue
- English
- Weight
- 435 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0340-5761
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## Abstract Tamoxifen, a nonsteroidal anti‐estrogen, is a potent genotoxic hepatocarcinogen in rats, with both tumor initiating and promoting properties. Recently it has been demonstrated that genotoxic carcinogens, in addition to exerting genotoxic effects, often cause epigenetic alterations and t
incidence of hepatocellular carcinoma was significantly higher among chronic hepatitis B virus carriers who are heavy drinkers than among hepatitis B virus carriers
The effects of single doses of tamoxifen (TAM; 0.5-5 mg/kg, i.v.) and chronic pretreatment with TAM (0.1-5.0 mg/kg/day, i.p. for 7 consecutive days) on letrozole (0.5 mg/kg, i.v.) pharmacokinetics were evaluated in female Sprague-Dawley rats. The plasma concentration-time profiles of letrozole (0.1-