Seven metabolites of venlafaxine, identified in several species, were examined for CNS pharmacological activity in rodents. The 0-desmethyl compound Wy-45,233, which is the major metabolite in man, had the greatest preclinical activity. This metabolite exhibited an antidepressant profile (monoamine
โฆ LIBER โฆ
Comparison of the effects of mianserin and its enantiomers and metabolites on a behavioral screen for antidepressant activity
โ Scribed by Timothy H. Hand; Gerard J. Marek; Lewis S. Seiden
- Publisher
- Springer
- Year
- 1991
- Tongue
- English
- Weight
- 635 KB
- Volume
- 105
- Category
- Article
- ISSN
- 0033-3158
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