Comparison of the diuretic effects of chemically diverse kappa opioid agonists in rats: nalfurafine, U50,488H, and salvinorin A
β Scribed by S. Inan; D. Y.-W. Lee; L. Y. Liu-Chen; A. Cowan
- Publisher
- Springer-Verlag
- Year
- 2008
- Tongue
- English
- Weight
- 213 KB
- Volume
- 379
- Category
- Article
- ISSN
- 0028-1298
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The effect of a selective kappa-opioid agonist, U-50, 488H, on wet-dog shaking (WDS) induced by hippocampal stimulation was investigated and compared with that produced by morphine. U-50, 488H, as well as morphine, inhibited the appearance of WDS in a dose-dependent manner. U-50, 488H was approximat
The present study was designed to investigate the effect of U-50, 488H, a highly selective kappa opioid agonist, on ipsilateral and contralateral circling behavior induced by methamphetamine and by apomorphine, respectively. U-50, 488H (3.2-10 mg/kg IP) by itself failed to induce either ipsilateral