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Comparison of the Dependence of the TD50 on Maximum Tolerated Dose for Mutagens and Nonmutagens

✍ Scribed by Gay Goodrnan; Richard Wilson

Book ID
109156803
Publisher
Springer
Year
1992
Tongue
English
Weight
752 KB
Volume
12
Category
Article
ISSN
1573-9147

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πŸ“œ SIMILAR VOLUMES

Temporal relationship of the induction o
Temporal relationship of the induction of tolerance and physical dependence after continuous intoxication with maximum tolerable doses of ethanol in rats
✍ Edward Majchrowicz; Walter A. Hunt πŸ“‚ Article πŸ“… 1976 πŸ› Springer 🌐 English βš– 576 KB

Rats were treated by intragastric intubation of a 20 % ethanol solution in doses of 9-15 g/kg in 3-5 fractions for 1-7 days. Both tolerance and physical dependence were demonstrated after this treatment with the maximum tolerable doses to only a few days. Tolerance was assessed by signs of severity