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Comparison of the Caco-2, HT-29 and the mucus-secreting HT29-MTX intestinal cell models to investigate Salmonella adhesion and invasion

✍ Scribed by Gagnon, Mélanie; Zihler Berner, Annina; Chervet, Noémie; Chassard, Christophe; Lacroix, Christophe

Book ID
120649759
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
968 KB
Volume
94
Category
Article
ISSN
0167-7012

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✍ Catherine Pontier; Jean Pachot; Roger Botham; Bernard Lenfant; Philippe Arnaud 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 410 KB

The permeability of 19 compounds in both the Caco-2/TC7 and HT29-MTX models was determined, and the ability of each model to predict intestinal absorption in humans was compared. Similar apparent permeability values (log P app ) were obtained in both models for the majority of compounds tested, and