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Comparison of the bioavailability of two slow release preparations of disopyramide

✍ Scribed by M. G. Bogaert; F. Belpaire; G. Wilde; R. A. Lefebvre

Publisher
Springer
Year
1991
Tongue
English
Weight
184 KB
Volume
40
Category
Article
ISSN
0031-6970

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✦ Synopsis

The bioavailability of two slow release preparations of disopyramide has been compared in a randomized cross-over trial of Rythmodan L.A. 250 mg b.d. and Dirytmin Durettes 300 mg b.d., given to 10 healthy volunteers. The plasma concentrations of disopyramide were measured on the 5th day of each treatment period. With both preparations, plasma concentrations were well sustained. The amount absorbed was slightly lower after Rythmodan L.A. than after Dirytmin Durettes, but the fluctuations over a dosing interval were significantly more pronounced for Dirytmin Durettes than for Rythmodan L.A.

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