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Comparison of the binding of optically pure (−)- and (+)-[3H]nicotine to rat brain membranes

✍ Scribed by Leo G. Abood; Susan Grassi; Helen D. Noggle

Publisher
Springer
Year
1985
Tongue
English
Weight
384 KB
Volume
10
Category
Article
ISSN
0364-3190

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3H]nicotine bound to rat cortical membranes in a biphasic manner consistent with previous models of receptor function. The kinetics of binding were characterized by a rapid component with a rate constant of 0.007 min-' nM-' and a slower component with an apparent rate constant of 0.024 min-'. Dissoc