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Comparison of tacrolimus with cyclosporin as primary immunosuppression in patients with hepatitis C virus infection after liver transplantation

โœ Scribed by Z Ben-Ari; E Mor; N Bar-Nathan; E Shaharabani; Z Shapira; R Tur-Kaspa


Book ID
117233147
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
57 KB
Volume
35
Category
Article
ISSN
0041-1345

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The outcome of hepatitis C virus (HCV) infection on patient and graft survival after orthotopic liver transplantation (OLT) has been controversial. An earlier experience with a higher dose of tacrolimus (H0.1 mg/kg/d intravenously and H0.2 mg/ kg/d orally) was associated with a worse clinical outcom

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The introduction of calcineurin inhibitors has improved graft survival in the last 25 years. [1][2][3] The superiority of tacrolimus over cyclosporine (CsA) was well established in preventing acute rejection and corticosteroid-resistant rejection from 3 large randomized trials after liver transplant