Comparison of strategies for selecting single nucleotide polymorphisms for case/control association studies
β Scribed by Qiqing Huang; Yun-xin Fu; Eric Boerwinkle
- Publisher
- Springer
- Year
- 2003
- Tongue
- English
- Weight
- 392 KB
- Volume
- 113
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Association studies assessing the relationship between a common polymorphism and disease generally compare allele frequencies in cases and controls. In such studies, a limited amount of information is often available about disease incidence in relatives. We hypothesised that more power
## Abstract Single nucleotide polymorphisms (SNPs) are becoming widely used as genotypic markers in genetic association studies of common, complex human diseases. For such association screens, a crucial part of study design is determining what SNPs to prioritize for genotyping. We present a novel p
## Abstract Multiple testing is a challenging issue in genetic association studies using large numbers of single nucleotide polymorphism (SNP) markers, many of which exhibit linkage disequilibrium (LD). Failure to adjust for multiple testing appropriately may produce excessive false positives or ov