Comparison of Stochastic Optimization Methods for All-Atom Folding of the Trp-Cage Protein

Comparison of two optimization methods t

Comparison of two optimization methods to derive energy parameters for protein folding: Perceptron and Z score

✍ Michele Vendruscolo; Leonid A. Mirny; Eugene I. Shakhnovich; Eytan Domany 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 222 KB 👁 1 views

Two methods were proposed recently to derive energy parameters from known native protein conformations and corresponding sets of decoys. One is based on finding, by means of a perceptron learning scheme, energy parameters such that the native conformations have lower energies than the decoys. The se