Comparison of spectral fitting methods for overlapping J-coupled metabolite resonances

✍ Scribed by A. Gonenc; V. Govind; S. Sheriff; A. A. Maudsley

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 207 KB
• Volume: 64
• Category: Article
• ISSN: 0740-3194
• DOI: 10.1002/mrm.22540

✦ Synopsis

Abstract

There is increasing interest in the use of two‐dimensional J‐resolved spectroscopic acquisition (multiecho) methods for in vivo proton magnetic resonance spectroscopy due to the improved discrimination of overlapping J‐coupled multiplet resonances that is provided. Of particular interest is the potential for discrimination of the overlapping resonances of glutamate and glutamine. In this study, a new time‐domain parametric spectral model that makes use of all available data is described for fitting the complete two‐dimensional multiecho data, and the performance of this method was compared with fitting of one‐dimensional spectra obtained following averaging multiecho data (echo time‐averaged) and single‐echo time PRESS (Point Resolved Spectroscopy) acquired spectra. These methods were compared using data obtained from a phantom containing typical brain metabolites and a human brain. Results indicate that improved performance and accuracy is obtained for the two‐dimensional acquisition and spectral fitting model. Magn Reson Med, 2010. © 2010 Wiley‐Liss, Inc.