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Comparison of Somatostatin Receptor Agonist and Antagonist for Peptide Receptor Radionuclide Therapy: A Pilot Study

✍ Scribed by Wild, D.; Fani, M.; Fischer, R.; Del Pozzo, L.; Kaul, F.; Krebs, S.; Fischer, R.; Rivier, J. E. F.; Reubi, J. C.; Maecke, H. R.; Weber, W. A.


Book ID
127260456
Publisher
The Society of Nuclear Medicine
Year
2014
Tongue
English
Weight
780 KB
Volume
55
Category
Article
ISSN
0161-5505

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We have evaluated the potential usefulness of radiolabelled [DTPA 0 ,Tyr 3 ]octreotide and [DOTA 0 ,Tyr 3 ]octreotide as radiopharmaceuticals for somatostatin receptor-targeted scintigraphy and radiotherapy. In vitro somatostatin receptor binding and in vivo metabolism in rats of the compounds were