Comparison of remifentanil with alfentanil or suxamethonium following propofol anaesthesia for tracheal intubation
✍ Scribed by R. Alexander; J. Booth; A. J. Olufolabi; H. E. El-Moalem; P. S. Glass
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 149 KB
- Volume
- 54
- Category
- Article
- ISSN
- 0003-2409
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✦ Synopsis
Sixty ASA physical status I and II, premedicated patients were administered propofol 2 mg.kg^−1^ and remifentanil 2 μg.kg^−1^ (group R), alfentanil 50 μg.kg^−1^ (group A) or suxamethonium 1 mg.kg^−1^ (group S) as a rapid bolus. One minute after study drug administration, tracheal intubation was performed. Intubation conditions were then scored. Excellent or good conditions were observed in only 35% in group R compared with groups S and A (100% and 85%, respectively; p < 0.001). The haemodynamic response to tracheal intubation was blunted in groups R and A compared with group S (p < 0.001). The mean heart rate in groups R and A was significantly lower than group S (p < 0.001). We conclude that remifentanil 2 μg.kg^−1^ given as a rapid bolus will not produce intubating conditions as good as those obtained with alfentanil 50 μg.kg^−1^ or suxamethonium 1 mg.kg^−1^ if administered after propofol 2 mg.kg^−1^.