Comparison of relative forced expiratory volume of one second with dynamic magnetic resonance imaging parameters in healthy subjects and patients with lung cancer
✍ Scribed by Christian Plathow; Christian Fink; Alexandra Sandner; Sebastian Ley; Michael Puderbach; Monika Eichinger; Astrid Schmähl; Hans-Ulrich Kauczor
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 483 KB
- Volume
- 21
- Category
- Article
- ISSN
- 1053-1807
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✦ Synopsis
Abstract
Purpose
To assess relative forced expiratory volume in one second (FEV1/vital capacity (VC)) in healthy subjects and patients with a lung tumor using dynamic magnetic resonance imaging (dMRI) parameters.
Materials and Methods
In 15 healthy volunteers and 31 patients with a non‐small‐cell lung carcinoma stage I (NSCLC I), diaphragmatic length change (LE1) and craniocaudal (CC) intrathoracic distance change within one second from maximal inspiration (DE1) were divided by total length change (LE~total~, DE~total~) as a surrogate of spirometric FEV1/VC using a true fast imaging with steady‐state precession (trueFISP) sequence (TE/TR = 1.7/37.3 msec, temporal resolution = 3 images/second). Influence of tumor localization was examined.
Results
In healthy volunteers FEV1/VC showed a highly significant correlation with LE1/LE~total~ and DE1/DE~total~ (r > 0.9, P < 0.01). In stage IB tumor patients, comparing tumor‐bearing with the non‐tumor‐bearing hemithorax, there was a significant difference in tumors of the middle (LE1/LE~total~ = 0.63 ± 0.05 vs. 0.73 ± 0.04, DE1/DE~total~ = 0.66 ± 0.05 vs. 0.72 ± 0.04; P < 0.05) and lower (P < 0.05) lung region. Stage IA tumor patients showed no significant differences with regard to healthy subjects.
Conclusion
dMRI is a simple noninvasive method to locally determine LE1/LE~total~ and DE1/DE~total~ as a surrogate of FEV1/VC in volunteers and patients. Tumors of the middle and lower lung regions have a significant influence on these MRI parameters. J. Magn. Reson. Imaging 2005;21:212–218. © 2005 Wiley‐Liss, Inc.