Comparison of quantitation methods for L-1210 cell populations and evaluation of selected cytotoxic agents in leukemic mice

✍ Scribed by C. T. Bauguess; Y. Y. Lee; J. W. Kosh; J. E. Wynn

• Publisher: John Wiley and Sons
• Year: 1981
• Tongue: English
• Weight: 404 KB
• Volume: 70
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600700107

✦ Synopsis

A more rapid cell-counting technique using an electronic cell counter was developed as an improvement over the slower hemocytometer method. The electronic counting method produced cell counts that had a smaller standard deviation but were not significantly different from the hemocytometer method. The acetate, hexanoate, and decanoate esters of p-N,N-bis(2-chloroethyl)aminophenol were investigated for acute toxicity in mice, effects on survival times, and effects on L-1210 cell populations in L-1210 leukemic mice. The decanoate ester was the least toxic compound and was most effective in lengthening the lifespan of the mice. The acetate and hexanoate esters were more effective in reducing L-1210 cell populations.

Keyphrases 0 p-N,N-Bis(2-chloroethyl)aminophenol-ester derivatives synthesized and evaluated for antileukemic activity and toxicity, comparison of two cell-counting methods 0 Antileukemic activityp-N,Nbis(2-chloroethyl)aminophenol ester derivatives, synthesis and evaluation for antileukemic activity and toxicity, comparison of two cell-counting methods