Comparison of pulmonary O6-methylguanine DNA adduct levels and Ki-ras activation in lung tumors from resistant and susceptible mouse strains

Comparison of pulmonary O6-methylguanine

Comparison of pulmonary O6-methylguanine dna adduct levels and Ki-ras activation in lung tumors from resistant and susceptible mouse strains

✍ Theodora R. Devereux; Catherine M. White; Monika E. Hegi; Arti C. Patel; Marshal 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 913 KB

## Abstract The role of __O__^6^‐methylguanine (O^6^MG) DNA adduct formation and persistence in the formation of 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK)—induced lung tumors from resistant C57BL/6 and susceptible A/J mice was investigated. In addition, the frequencies of pulmonary tumor