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Comparison of postpartum pain treatments using a sequential trial design: II. Naproxen versus paracetamol

✍ Scribed by E. Skovlund; G. Fyllingen; H. Landre; B.-I. Nesheim

Publisher: Springer
Year: 1991
Tongue: English
Weight: 398 KB
Volume: 40
Category: Article
ISSN: 0031-6970
DOI: 10.1007/bf00279965

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✦ Synopsis

The efficacy of naproxen and paracetamol in relieving uterine cramps has been compared in a sequential trial. The treatments did not differ significantly in a two-sided test in 56 patients. A corresponding fixed sample test would have required 140 patients to obtain the same significance level and power. In addition to uterine pain, the effect on episiotomy pain was also estimated at the termination of the trial. Again, there seemed to be no difference between naproxen and paracetamol.

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Comparison of postpartum pain treatments

Comparison of postpartum pain treatments using a sequential trial design. I. Paracetamol versus placebo

✍ E. Skovlund; G. Fyllingen; H. Landre; B. -I. Nesheim 📂 Article 📅 1991 🏛 Springer 🌐 English ⚖ 490 KB

A new sequential test has been used to compare the effect of paracetamol and placebo on uterine cramping. Paracetamol was significantly superior to placebo at the 5% level. 75 patients were included in the trial, whereas in a fixed sample study 90 patients would have been required to obtain the same