Comparison of PET measurements of cerebral blood flow and glucose metabolism for the localization of human epileptic foci

✍ Scribed by Deborah B Leiderman; Marshall Balish; Susumu Sato; Conrad Kufta; Pat Reeves; William D Gaillard; William H Theodore

• Publisher: Elsevier Science
• Year: 1992
• Tongue: English
• Weight: 462 KB
• Volume: 13
• Category: Article
• ISSN: 0920-1211
• DOI: 10.1016/0920-1211(92)90071-z

✦ Synopsis

We compared the relative sensitivity of two interictal PET techniques, bolus injection of [15O] labeled water for estimation of cerebral blood flow (H2(15)O CBF-PET), and 18F 2-deoxyglucose (18FDG-PET) for cerebral glucose metabolism (CMRglc), and T2-weighted magnetic resonance imaging, in 28 patients with medically intractable complex partial seizures undergoing evaluation for surgery. There were statistically significant associations between lateralization by 18FDG-PET, and MRI, but not H2(15)O CBF-PET, and lateralization of the epileptic focus as defined by scalp-sphenoidal ictal EEG. Fifteen patients had surgery or subdural electrodes. 18FDG-PET was more closely associated with a good outcome than H2(15)O CBF-PET, which, in addition, showed hypoperfusion contralateral to the epileptic temporal lobe in several cases. H2(15)O sensitivity may have been reduced by technical factors, but 18FDG-PET appears to be more specific for localization of epileptic zones.