Comparison of permissible source region and multispectral data using efficient bioluminescence tomography method
✍ Scribed by Chenghu Qin; Shouping Zhu; Jinchao Feng; Jianghong Zhong; Xibo Ma; Ping Wu; Jie Tian
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 837 KB
- Volume
- 4
- Category
- Article
- ISSN
- 1864-063X
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✦ Synopsis
Abstract
As a novel molecular imaging technology, bioluminescence tomography (BLT) has become an important tool for biomedical research in recent years, which can perform a quantitative reconstruction of an internal light source distribution with the scattered and transmitted bioluminescent signals measured on the external surface of a small animal. However, BLT is severely ill‐posed because of complex photon propagation in the biological tissue and limited boundary measured data with noise. Therefore, sufficient a priori knowledge should be fused for the uniqueness and stability of BLT solution. Permissible source region strategy and spectrally resolved measurements are two kinds of a priori knowledge commonly used in BLT reconstruction. This paper compares their performance with simulation and in vivo heterogeneous mouse experiments. In order to improve the efficiency of large‐scale source restoration, this paper introduces an efficient iterative shrinkage thresholding method that not only has faster convergence rate but also has better reconstruction accuracy than the modified Newton‐type optimization approach. Finally, a discussion of these two kinds of a priori knowledge is given based on the comparison results. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)