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Comparison of peripheral and central administration of naloxone in precipitating abstinence in morphine-dependent rats

✍ Scribed by Bell, Jeffrey; Adler, Martin W.

Book ID
122712847
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
521 KB
Volume
21
Category
Article
ISSN
0376-8716

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Assessment of precipitated abstinence in
Assessment of precipitated abstinence in morphine- dependent rats
✍ Eddie Wei πŸ“‚ Article πŸ“… 1973 πŸ› Springer 🌐 English βš– 523 KB

An experimental model is described for quantifying the precipitated abstinence syndrome in morphine-dependent rats. Male rats were made dependent on morphine by subcutaneous implantation of a morphine pellet and the abstinence syndrome precipitated by intraperitoneal injection of naloxone hydrochlor