Comparison of mouse bioassay and immunoprecipitation assay for botulinum toxin antibodies
โ Scribed by Hanna, P. A; Jankovic, J.; Vincent, A.
- Book ID
- 119970269
- Publisher
- BMJ Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 557 KB
- Volume
- 66
- Category
- Article
- ISSN
- 0022-3050
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Measurements of the efficacy of novel botulinum toxin antagonists can be based on classical bioassays of toxin concentration. However, the relative sensitivities of in vivo and in vitro assays to the effects of antagonists are not necessarily correlated with the sensitivities of the assays to toxin.
## Abstract With the advent of a commercial preparation of botulinum toxin type B (BTโB) for treatment of cervical dystonia detection of antibodies against BTโB (BTโBโAB) becomes necessary. For this purpose, we carried out a mouse diaphragm assay (MDA) by continuous measurement of the twitch force