The elevations of blood urea nitrogen and serum creatinine caused by cis-platinum in rats can be prevented by a combination of procedures centered around the administration of sodium N-methyl-N-dithiocarboxyglucamine (NaG), before and very soon after the cis-platinum is administered in hypertonic (4
Comparison of methods of evaluating nephrotoxicity of cis-platinum
โ Scribed by Jones, Brian R; Bhalla, Ravi B; Mladek, Jiri; Kaleya, Ronald N; Gralla, Richard J; Alcock, Nancy W; Schwartz, Morton K; Young, Charles W; Reidenberg, Marcus M
- Book ID
- 109843008
- Publisher
- Nature Publishing Group
- Year
- 1980
- Tongue
- English
- Weight
- 428 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0009-9236
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The nephrotoxicity of cis-platinum (CDDP) in the rat can be controlled throughout a series of weekly administrations of CDDP (each of 5 mg kg-', i.v.) for at least three weeks by a combination of protective measures involving pretreatment with dithiocarbamates and diuretics and the administration of
We studied renal function in nine patients with disseminated testicular carcinoma before and after remission-induction and maintenance therapy with a drug combination containing cis-platinum. The median glomerular filtration rate (GFR) decreased during remission-induction therapy from 146 to 118 ml/