𝔖 Bobbio Scriptorium
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COMPARISON OF METHODS FOR THE PREDICTION OF PHENYTOIN CONCENTRATIONS

✍ Scribed by A. Vázquez Rodríguez; D. Santos Buelga; A. C. Alonso González; M. J. García Sánchez; A. Domínguez-Gil Hurlé

Book ID
114738253
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
366 KB
Volume
16
Category
Article
ISSN
0269-4727

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A method for prediction of phenytoin lev
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Phenytoin (PHT) administration is complicated by saturation kinetics within the therapeutic range, causing marked changes in drug concentration with small changes in dose. The "half-life" increases with concentration, varying from 8-24 hr up to weeks, making it difficult to obtain the steady state l