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Comparison of in vivo and in vitro effects of chloroquine on hepatic lysosomes

✍ Scribed by James P. Filkins

Book ID
115770142
Publisher
Elsevier Science
Year
1969
Tongue
English
Weight
508 KB
Volume
18
Category
Article
ISSN
0006-2952

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πŸ“œ SIMILAR VOLUMES

Role of lysosomes in hepatic accumulatio
Role of lysosomes in hepatic accumulation of chloroquine
✍ Anna C. Macintrye; David J. Cutler πŸ“‚ Article πŸ“… 1988 πŸ› John Wiley and Sons 🌐 English βš– 455 KB

At therapeutic free concentrations (120-360 nM in rheumatoid arthritis), the accumulation ratio for chloroquine (7-chloro-4-[[4-(diethylamino)-1-methylbutyl]amino]-quinoline; CQ) in viable isolated rat hepatocytes is 795 +/- 33, which is of the same order of magnitude as in vivo hepatic uptake in th