✦ LIBER ✦

Comparison of in vitro and in vivo release characteristics of acetaminophen from gradient matrix systems

✍ Scribed by Elvira M. G. Van Bommel; Maikel Raghoebar; Josef J. Tukker

Publisher: John Wiley and Sons
Year: 1991
Tongue: English
Weight: 316 KB
Volume: 12
Category: Article
ISSN: 0142-2782
DOI: 10.1002/bdd.2510120506

No coin nor oath required. For personal study only.

✦ Synopsis

An effort was made to correlate the in vivo and in vitro release data of acetaminophen from two formulations of a recently developed controlled-release system, the Gradient Matrix System (GMS-1 and GMS-2). The in vivo release curves, obtained by deconvolution of the plasma concentration time plots, showed a small inter-subject variability. GMS-1 with fastest in vitro release also showed fastest in vivo release. A good relationship was only found after time-scaling of the release data.

KEY WORDS Oral controlled delivery Gradient matrix system In vivolln vitro correlation Acetaminophen

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