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Comparison of hypervariable regions (HVR1 and HVR2) in positive- and negative-stranded hepatitis C virus RNA in cancerous and non-cancerous liver tissue, peripheral blood mononuclear cells and serum from a patient with hepatocellular carcinoma

✍ Scribed by Satoru Saito; Nobuyuki Kato; Makoto Hijikata; Toshiaki Gunji; Masayuki Itabashi; Masaaki Kondo; Katsuaki Tanaka; Kunitada Shimotohno

Publisher: John Wiley and Sons
Year: 1996
Tongue: French
Weight: 504 KB
Volume: 67
Category: Article
ISSN: 0020-7136
DOI: 10.1002/(sici)1097-0215(19960717)67:2<199::aid-ijc9>3.0.co;2-o

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Hepatitis C virus (HCV) has many genotypes which are closely associated with the severity of chronic hepatitis and the response to antiviral therapy. Although HCV is essentially hepatotropic, several lines of evidence suggest that this virus can infect peripheral blood mononuclear cells (PBMC) in mo