Comparison of Hepatotoxicity of 1,2-, 1,3- and 1,4-Dibromobenzenes: the Dynamics of Changes of Selected Parameters of Liver Necrosis in Acute Poisoning in Mice

✍ Scribed by J. A. Szymańska; E. Bruchajzer; S. Sporny

• Publisher: John Wiley and Sons
• Year: 1996
• Tongue: English
• Weight: 618 KB
• Volume: 16
• Category: Article
• ISSN: 0260-437X
• DOI: 10.1002/(sici)1099-1263(199601)16:1<35::aid-jat307>3.0.co;2-t

✦ Synopsis

Various doses of dibromobenzene isomers (1,2-dBB, 1,3-dBB, 1,4-dBB) were administered (i.p.) to BALB mice. The levels of reduced glutathione (GSH) and malondialdehyde (MDA) in the liver, and glutamatepyruvate transaminase (GPT) (EC.2.6.1.2) y-glutamyltransferase (y-GT) (EC.2.3.2.2) and triglycerides (TG) in the serum were estimated. A considerable decrease of GSH was observed between 2 and 12 h after administration of the compounds. Increases in serum GPT activity (up to 100-fold) and y-GT (three-to fivefold) were observed after treatment using 1,2-and 1,3-dibromobenzenes; TG decreased in concentration initially and then slightly increased.

Histopathological examination confirmed the strong necrotic effect of 12-and 1,S-dBB isomers. No such changes (elevation of serum GPT activity and necrosis) were noticed after 1,4-dBB.