Comparison of hepatitis B X gene mutation between patients with hepatocellular carcinoma and patients with chronic hepatitis B
β Scribed by Wenmei Fan; Bingyi Shi; Hongshan Wei; Guosheng Du; Shujing Song
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 691 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0920-8569
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## Abstract Specific mutations in the hepatitis B virus (HBV) genome have been reported to be associated with the development of hepatocellular carcinoma (HCC). The goal of this study was to determine whether mutations in the HBV X gene are associated with the development of HCC in hepatitis B pati
## Abstract Chronic hepatitis B infection is a major cause of hepatocellular cancer (HCC). The pathogenesis of the carcinogenesis is not fully understood. Viral proteins such as the X protein and the truncated middle S protein have been implicated to be transactivators. In order to investigate whet
We studied the frequency of hepatitis B virus replication in Chinese patients with hepatocellular carcinoma. Hepatitis B e antigen and hepatitis B virus DNA could be detected in the sera of 28% and 47% of 116 HBeAg-positive patients, but not in the sera of 15 HBsAg-negative patients. Replicative for