Comparison of hemoglobin A1c and hemoglobin A1 in diabetic patients

✍ Scribed by Thomas M. James; James E. Davis; Jay M. McDonald; Julio V. Santiago; Jack H. Ladenson

• Publisher: Elsevier Science
• Year: 1981
• Tongue: English
• Weight: 237 KB
• Volume: 14
• Category: Article
• ISSN: 0009-9120
• DOI: 10.1016/0009-9120(81)90135-1

✦ Synopsis

Hemoglobin A1 (HbA1) and hemoglobin Alc (HbAlc) values were compared in 934 samples from 686 subjects with diabetes mellitus. Linear regression analysis revealed the two parameters to be highly related with HbAI ----1.18 Hb'Alc + 1.67, and a correlation coefficient of 0.97. Samples with HbAI greater than predicted from the measured HbAIc had been stored significantly longer ("~1 day) than other samples, suggesting that sample storage may slightly alter the relationship between these parameters. Serial HbAI and HbAIc values in all 9 patients for whom data was available from at least 5 time points changed in parallel regardless of the time interval between sampling or the magnitude of the interval change of HbAI and HbAIc. These data indicate that the potentially simpler measurement of HbA1 gives results equivalent to HbAIc for clinical applications.