Comparison of four modulators of drug metabolism as protectants against the hepatotoxicity of the novel antitumor drug yondelis (ET-743) in the female rat and in hepatocytes in vitro

Dietary agent indole-3-carbinol protects

Dietary agent indole-3-carbinol protects female rats against the hepatotoxicity of the antitumor drug ET-743 (trabectidin) without compromising efficacy in a rat mammary carcinoma

✍ Sarah Donald; Richard D. Verschoyle; Peter Greaves; Tina Colombo; Massimo Zucche 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 French ⚖ 292 KB

## Abstract ET‐743, an experimental antitumor drug with promising activity in sarcoma, breast and ovarian carcinoma, is currently under phase 2 clinical evaluation. It is hepatotoxic in animals and patients. We tested the hypothesis that indole‐3‐carbinol (I3C), the hydrolysis product of glucosinol