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Comparison of first-pass Gd-DOTA and FAIRER MR perfusion imaging in a rabbit model of pulmonary embolism

✍ Scribed by Shella D. Keilholz; Vu M. Mai; Stuart S. Berr; Naomi Fujiwara; Klaus D. Hagspiel


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
315 KB
Volume
16
Category
Article
ISSN
1053-1807

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✦ Synopsis


Abstract

Purpose

To compare the sensitivity of contrast‐enhanced magnetic resonance imaging (MRI) and arterial spin labeling to perfusion deficits in the lung.

Materials and Methods

A rabbit model of pulmonary embolism was imaged with both flow‐sensitive alternating inversion recovery with an extra radiofrequency pulse (FAIRER) arterial spin labeling and Gd‐DOTA enhanced MRI. The signal‐to‐noise ratio (SNR) was measured in the area of the perfusion deficit and the normal lung for both techniques.

Results

The defect was readily visible in all images. The normal lung had an average of 3.8 ± 1.2 times the SNR of the unperfused lung with the arterial spin labeling technique, and approximately 13.7 ± 3.3 times the SNR with the contrast‐enhanced technique.

Conclusion

Gd‐DOTA enhanced MRI provides higher SNR in pulmonary perfusion imaging; however, arterial spin labeling is also adequate and may be used when repeated studies are indicated. J. Magn. Reson. Imaging 2002;16:168–171. © 2002 Wiley‐Liss, Inc.


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