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Comparison of enhancement patterns of histologically confirmed hepatocellular carcinoma between gadoxetate- and ferucarbotran-enhanced magnetic resonance imaging

✍ Scribed by Masahiro Okada; Yasuharu Imai; Tonsok Kim; Sachiyo Kogita; Manabu Takamura; Seishi Kumano; Hiromitsu Onishi; Masatoshi Hori; Kazuto Fukuda; Norio Hayashi; Kenichi Wakasa; Michiie Sakamoto; Takamichi Murakami

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
564 KB
Volume
32
Category
Article
ISSN
1053-1807

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✦ Synopsis

Abstract

Purpose

To compare enhancenent patterns of hepatocellular carcinoma (HCC) and dysplastic nodule (DN) between gadoxetate‐ and ferucarbotran‐enhanced MRI.

Materials and Methods

Patients recruited from ultrasound surveillance for HCC in chronic liver diseases were enrolled in this prospective study approved by institutional review board. Thirty‐six patients with 37 histologically proven HCC, including 22 well‐differentiated HCCs (wHCC), 15 moderately to poorly differentiated HCCs (mpHCCs), and 4 DNs, underwent gadoxetate‐enhanced and ferucarbotran‐enhanced MRI. We compared hepatobiliary phase image of gadoxetate‐enhanced MRI with ferucarbotran‐enhanced MR image regarding signal intensity of HCC and DN relative to surrounding liver parenchyma. We calculated contrast ratios between tumor and liver on pre‐enhancement, hepatobiliary phase of gadoxetate‐enhanced MRI and ferucarbotran‐enhanced MRI.

Results

On ferucarbotran‐enhanced MRI, all mpHCCs showed hyper‐intensity, while 14 wHCCs (14/22;63%) showed iso‐intensity. On hepatobiliary phase of gadoxetate‐enhanced MRI, 13 mpHCCs (13/15;86%) and 20 wHCCs (20/22;91%) showed hypo‐intensity. Two DNs and the other two showed iso‐ and hypo‐intensity, respectively, on gadoxetate‐enhanced MRI, whereas all DNs revealed iso‐intensity on ferucarbotran‐enhanced MRI. Gadoxetate‐postcontrast ratio was significantly lower than ferucarbotran‐postcontrast ratio in wHCC (P = 0.015).

Conclusion

The uptake function of hepatocytes that are targeted by gadoxetate is more sensitive than that of Kupffer cells targeted by ferucarbotran in stepwise hepatocarcinogenesis. J. Magn. Reson. Imaging 2010;32:903–913. © 2010 Wiley‐Liss, Inc.

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