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Comparison of DNA alkylation, fragmentation, and repair in maternal and fetal tissues of pregnant rats treated with a single dose of ethyl methanesulfonate, ethyl-N-nitrosourea, N-nitrosodiethylamine, and methyl-N-nitrosourea

✍ Scribed by Luigi Robbiano; Angela Parodi; Simonetta Venturelli; Giovanni Brambilla

Book ID: 112213397
Publisher: John Wiley and Sons
Year: 1989
Tongue: English
Weight: 729 KB
Volume: 9
Category: Article
ISSN: 0270-3211
DOI: 10.1002/tcm.1770090304

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## Abstract Formation and loss of methylated purines in DNA of various fetal and maternal tissues were measured up to 7 days following intravenous administration of __N__‐[^14^C]methyl‐__N__‐nitrosourea to rats on the 21st day of gestation. Methylation products were detected in all tissues examined