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Comparison of DGGE and immunohistochemistry in the detection ofTP53variants in a Brazilian sample of sporadic breast tumors

✍ Scribed by Vitor Rezende da Costa Aguiar; Melissa de Freitas Cordeiro-Silva; Alex Assis de Carvalho; Iúri Drumond Louro


Book ID
106470781
Publisher
Springer
Year
2010
Tongue
English
Weight
163 KB
Volume
38
Category
Article
ISSN
0301-4851

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The p53 mutational status of 226 representative primary breast cancer samples, derived from a population-based cohort, was analyzed using cDNA-based sequencing. The results were compared with those obtained with immunohistochemistry (IHC) on microwave-treated paraffin sections and the p53 specific l