Comparison of delayed hepatobiliary imaging using99mTc-Sn-N-pyridoxyl-5-methyltryptophan and67Ga-citrate imaging for diagnosis of hepatocellular carcinoma
✍ Scribed by Y. Hasegawa; S. Nakano; S. Ishiguro; S. Imaoka; Y. Sasaki; S. Tanaka; H. Kasugai; J. Kojima; S. Ishigami
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 1009 KB
- Volume
- 14-14
- Category
- Article
- ISSN
- 0340-6997
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✦ Synopsis
Images were obtained both with a biliary agent, 99mTc-Sn-N-pyridoxyl-5-methyltryptophan (99mTc-PMT), and with 67Ga-citrate in 40 cases of hepatocellular carcinoma and in 43 cases of other hepatic diseases and results were compared. Positive results were obtained by delayed 99mTc-PMT imaging in 25 (63%) of 40 cases of hepatoma: the hepatic tumor showed increased uptake in 18 cases (45%) and equilibrated uptake in 7 cases (18%). Positive 67Ga-citrate imaging was found in 28 (70%) of the 40 cases of hepatoma: increased uptake was seen in 24 cases (60%) and equilibrated uptake in 4 cases (10%). Of 15 cases of hepatoma giving negative results in the 99mTc-PMT study, 7 cases (47%) took up 67Ga-citrate, and 6 of these showed increased 67Ga-citrate uptake by the hepatic tumors. A certain relation existed between the degree of histological differentiation of hepatomas and the intensity of 99mTc-PMT uptake by those tumors, while such a histological correlation was denied for 67Ga-citrate uptake by the tumors. Delayed 99mTc-PMT imaging is preferable to 67Ga-citrate imaging for increasing the specificity of diagnosis of hepatoma. 67Ga-citrate should be used in those cases that do not give positive results with 99mTc-PMT.