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Comparison of cytocompatibility of zein film with other biomaterials and its degradability in vitro

✍ Scribed by Qing-Shen Sun; Jian Dong; Zhi-Xin Lin; Bin Yang; Jin-Ye Wang

Publisher
Wiley (John Wiley & Sons)
Year
2005
Tongue
English
Weight
326 KB
Volume
78
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

Cytocompatibility of particle zein (Pzein) and film zein (Fzein) was evaluated and compared with polyhydroxybutyrate (PHB), its copolymer poly(hydroxybutyrate‐co‐hydroxyvalerate) (PHBV), polylactic acid (PLA), and collagen, using HL‐7702 cells, in terms of cell attachment rate within 3 h, and cell viabilities at 3 and 6 days determined by the 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyl tetrazolium bromide (MTT) method. The zein degradation test was carried out using collagenase and trypsin, and the degradation product was added to the culture medium at different concentrations in order to examine the concentration‐dependent cytotoxic effect. Result: The adhesion rate of the HL‐7702 cells on both Pzein and Fzein was higher than that on collagen film. Cell viabilities were higher on both Pzein and Fzein than on films of PLA, PHB, PHBV, and collagen from fish skin. Zein can be degraded by both trypsin and collagenase, and the degradation product can enhance cell viability within a certain range of concentrations. © 2005 Wiley Periodicals, Inc. Biopolymers 78: 268–274, 2005

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