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Comparison of cervical cancer screening strategies incorporating different combinations of cytology, HPV testing, and genotyping for HPV 16/18: results from the ATHENA HPV study

✍ Scribed by Cox, J. Thomas; Castle, Phillip E.; Behrens, Catherine M.; Sharma, Abha; Wright, Thomas C.; Cuzick, Jack

Book ID: 123527884
Publisher: Elsevier Science
Year: 2013
Tongue: English
Weight: 619 KB
Volume: 208
Category: Article
ISSN: 1097-6868
DOI: 10.1016/j.ajog.2012.11.020

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## Abstract p16^INK4a^, a cell cycle regulation protein, accumulates in abnormal epithelial cells infected with high‐risk human papilloma virus (HPV). In immunostaining studies, p16^INK4a^ has shown potential as a marker of high grade cervical intraepithelial neoplasia (CIN) and invasive cervical c