Comparison of bopindolol and atenolol in chronic stable angina pectoris
โ Scribed by P. Fitscha; W. Meisner; B. Tiso
- Publisher
- Springer
- Year
- 1990
- Tongue
- English
- Weight
- 350 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0031-6970
No coin nor oath required. For personal study only.
โฆ Synopsis
The efficacy of bopindolol and atenolol in the treatment of patients with chronic stable angina pectoris have been compared in a double blind, randomized study. Both bopindolol 1 mg and atenolol 100 mg for 6 weeks increased mean exercise time (25% and 22%, respectively, compared to placebo), time to angina (27% and 25%), and time to 1 mm of ST-segment depression (32% and 20%). Both drugs reduced ST-segment depression similarly at maximal and submaximal work levels. There was no significant difference in their antianginal efficacy.
๐ SIMILAR VOLUMES
The antianginal effects ofbeta-adrenoceptor antagonists are achieved by a reduction in myocardial oxygen demand. This is a rational approach to treatment in patients whose angina is caused by a fixed stenosis. However, dynamic coronary vasospasm is an important factor in patients with chronic stable