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Comparison of a point mutation assay with a line probe assay for the detection of the major mutations in the HIV-1 reverse transcriptase gene associated with reduced susceptibility to nucleoside analogues

✍ Scribed by J.R. Clarke; S. Kaye; Abael G. Babiker; Malmolm H. Hooker; R. Tedder; J.N. Weber

Book ID: 114139506
Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 85 KB
Volume: 88
Category: Article
ISSN: 0166-0934
DOI: 10.1016/s0166-0934(00)00173-7

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Prevalence of the mutational pattern E44

Prevalence of the mutational pattern E44D/A and/or V118I in the reverse transcriptase (RT) gene of HIV-1 in relation to treatment with nucleoside analogue RT inhibitors

✍ Brigitte Montes; Michel Segondy 📂 Article 📅 2002 🏛 John Wiley and Sons 🌐 English ⚖ 93 KB

## Abstract It has been reported that a new pattern of mutations, E44D/A and/or V118I, in the reverse transcriptase (RT) gene of HIV‐1 confers a moderate level of resistance to lamivudine in the absence of the M184V mutation. The prevalence of this mutational pattern was studied in HIV‐1 isolates o