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Comparison by mass spectrometry of ring cleavage in barbituric acid and 5-fluorobarbituric acid derivatives

✍ Scribed by Darryl D. Desmarteau; Giuseppe Resnati; Donata Favretto; Pietro Traldi

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 543 KB
Volume: 27
Category: Article
ISSN: 1076-5174
DOI: 10.1002/oms.1210270309

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The mass spectrometric behaviour of barbituric acid and 1,3‐dimethylbarbituric acid was compared with that of the corresponding 5,5‐difluoro derivatives and of some 5‐fluoro‐5‐alkyl derivatives in order to study the influence of fluorine in the fragmentation processes. This investigation, performed using both electron impact ionization and positive‐ and negative‐ion fast atom bombardment, evidences well the role of fluorine in barbiturate ring bond cleavages.

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