Comparison between (RS)-nipecotic acid and GABA transport in cultured astrocytes: Coupling with two sodium ions
โ Scribed by O. M. Larsson; A. Schousboe
- Book ID
- 105016994
- Publisher
- Springer
- Year
- 1981
- Tongue
- English
- Weight
- 495 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0364-3190
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๐ SIMILAR VOLUMES
## Abstract The influence of sodium ions on GABA uptake into astrocytes in primary cultures has been investigated performing kinetic analysis of GABA uptake at different sodium concentrations in the range 16 to 151 mM. These investigations reveal that sodium affects both the K~m~ and the V~max~ of
The coupling ratio between sodium and GABA or the GABA analog, (RS)- nipecotic acid, in neuronal and glial uptake of GABA or nipecotic acid was investigated as a function of the morphological differentiation of these cell types in primary cultures. Both in neurons and astrocytes a high-affinity upta