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Comparison between (RS)-nipecotic acid and GABA transport in cultured astrocytes: Coupling with two sodium ions

โœ Scribed by O. M. Larsson; A. Schousboe


Book ID
105016994
Publisher
Springer
Year
1981
Tongue
English
Weight
495 KB
Volume
6
Category
Article
ISSN
0364-3190

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GABA uptake in astrocytes in primary cul
โœ O. M. Larsson; L. Hertz; Dr. A. Schousboe ๐Ÿ“‚ Article ๐Ÿ“… 1980 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 529 KB

## Abstract The influence of sodium ions on GABA uptake into astrocytes in primary cultures has been investigated performing kinetic analysis of GABA uptake at different sodium concentrations in the range 16 to 151 mM. These investigations reveal that sodium affects both the K~m~ and the V~max~ of

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The coupling ratio between sodium and GABA or the GABA analog, (RS)- nipecotic acid, in neuronal and glial uptake of GABA or nipecotic acid was investigated as a function of the morphological differentiation of these cell types in primary cultures. Both in neurons and astrocytes a high-affinity upta