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Comparison between inhibition of protein kinase C and antagonism of calmodulin by tamoxifen analogues

✍ Scribed by Martin G. Rowlands; Joanna Budworth; Michael Jarman; Ian R. Hardcastle; Raymond McCague; Andreas Gescher

Book ID
115784321
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
423 KB
Volume
50
Category
Article
ISSN
0006-2952

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Inhibition of protein kinase C and calmo
Inhibition of protein kinase C and calmodulin by the geometric isomers cis- and trans-tamoxifen
✍ Catherine A. O'Brian; Constantin G. Ioannides; Nancy E. Ward; Rob M. Liskamp πŸ“‚ Article πŸ“… 1990 πŸ› Wiley (John Wiley & Sons) 🌐 English βš– 648 KB

## SYNOPSIS The triphenylethylene antiestrogen trans-tamoxifen is an effective antitumor agent used in the treatment of human breast cancer. While the antiestrogenic activity of trans- tamoxifen clearly plays an important role in its tumoricidal action, some of the biological effects of trans-tamo