Comparison between exercise and trans-oesophageal atrial pacing in patients with coronary artery disease: technetium-99m methoxy isobutyl isonitrile simultaneous evaluation of ventricular function and myocardial perfusion
✍ Scribed by Alberto Cuocolo; Maurizio Santomauro; Leonardo Pace; Luigi Celentano; Antonio Nappi; Emanuele Nicolai; Massimo Chiariello; Marco Salvatore
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 837 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0340-6997
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✦ Synopsis
In this study we compared the results of exercise and trans-oesophageal atrial pacing (TAP) technetium-99m methoxyisobutyl isonitrile (99mTc-SESTAMI-BI) cardiac imaging in the evaluation of left ventricular (LV) function and myocardial perfusion in patients with angiographically proven coronary artery disease. Ten patients (8 men and 2 women, mean age 59 4-_ 6 years) were submitted to 3 separate injections of 99mTc-SES-TAMIBI, one under control conditions, one after exercise and one after TAP. LV ejection fraction, as measured by electrocardiogram (ECG) gated first pass, decreased from 49_ 5% under control conditions to 42-t-6% during exercise (P < 0.05 versus control) and to 43 4-8% during TAP (P<0.05 versus control and insignificant change versus exercise). Segmental myocardial perfusion analysis was performed on a total of 150 myocardial segments. On both exercise and TAP 99mTc-SESTA-MIBI studies, 103 segments (69% of the total) were normal, 32 (21%) had reversible, and 15 (10%) irreversible, perfusion defects. Relative regional tracer uptake was not statistically different between exercise and TAP in normal regions (91.1 __ 9.1% versus 90.7 ___ 8.5 %, respectively), in regions with reversible (61.9+_12% versus 62.4 4-10.4%, respectively) and irreversible perfusion defects (55.8 4-7.8% versus 58.8 4-9.5%, respectively). Our results demonstrated that 99mTc-SESTAMIBI TAP cardiac imaging shows similar results to 99mTc-SESTAMI-B! exercise myocardial scintigraphy in the assessment of LV function and myocardial perfusion in patients with coronary artery disease.