Comparison between a 2- and 3-grade system in predicting metastatic-free survival in extremity soft-tissue sarcoma
✍ Scribed by Kandel, Rita A.; Bell, Robert S.; Wunder, Jay S.; O'Sullivan, Brian; Catton, Charles N.; White, Lawrence M.; Davis, Aileen M.
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 94 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0022-4790
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✦ Synopsis
Background and Objectives:
The purpose of this study was to determine whether a histologic grading system consisting of 2 or 3 categories had better discrimination for predicting metastasis-free survival in extremity soft-tissue sarcoma. Methods: One hundred thirty patients with nonmetastatic soft-tissue sarcoma were identified and the histologic grade (3-grade system) for each tumor was determined. For the 2-grade system, grade was determined by collapsing 3 grades into 2. The Kaplan-Meier method was used to estimate disease free survival. Results: By use of a 3-grade system, grade 2 tumors showed a 5.2-fold and grade 3 tumors a 9-fold increased risk of systemic relapse when compared with grade 1 tumors. When grade 2 and 3 tumors were combined, they had a 2.6-fold increased risk of systemic relapse compared with grade 1 tumors. When grade 1 and 2 tumors were combined, grade 3 tumors had an 8.4-fold risk of relapse. After data were controlled for size and depth of tumor, each increase in grade in the 3-grade system showed a successive 2.3-fold increase in risk of systemic relapse. Conclusions: A 3-grade system may be more appropriate for predicting systemic relapse than 2 grades. A prospective study is required to confirm this.