Hic-5 is a paxillin homologue with four LIM domains in its C-terminal region, localized mainly in focal adhesions in normal fibroblasts. Hic-5 is also known to associate with focal adhesion kinase (FAK) or the related CAK, and with vinculin. In the present study, we examined changes in Hic-5 and pa
✦ LIBER ✦
Comparing the mechanical influence of vinculin, focal adhesion kinase and p53 in mouse embryonic fibroblasts
✍ Scribed by Anna H. Klemm; Gerold Diez; Josè-Luis Alonso; Wolfgang H. Goldmann
- Book ID
- 116297980
- Publisher
- Elsevier Science
- Year
- 2009
- Tongue
- English
- Weight
- 184 KB
- Volume
- 379
- Category
- Article
- ISSN
- 0006-291X
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## Abstract We examined the consequences of v‐Crk expression in mouse embryo fibroblasts deficient Src family kinases or p130CAS. We found that Src kinases are essential for p130CAS/v‐Crk signaling leading to FAK phosphorylation and cell migration in which Src is likely to mediate the focal adhesio