Comparative use of solvent-free KF-A12O3 and K2CO3 in acetone in the synthesis of quinoxaline 1,4-dioxide derivatives designed as antimalarial drug candidates

✍ Scribed by L. M. Lima; B. Zarranz; A. Marin; B. Solano; E. Vicente; S. Perez Silanes; I. Aldana; A. Monge

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2005
• Tongue: English
• Weight: 85 KB
• Volume: 42
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570420718

✦ Synopsis

In this paper we describe two new basic conditions for the synthesis of quinoxaline 1,4-dioxide derivatives in moderate to good yields. These conditions, exemplified by the use of K 2 CO 3 in acetone or KF/Al 2 O 3 in the absence of an organic solvent, were reproducible and applicable to the synthesis of 2-(carboethoxy)-3phenylquinoxaline 1,4-dioxide derivatives substituted in position 4 with electron-donating or electron-withdrawing groups.